GitHub - houndcl/PAINSfilter: PAINS (Pan Assay Interference Compounds) are either reactive, fluorescent, strongly colored, metal-trapping, toxin-trapping, or able to alter proteins chemically without fitting specifically into a binding site. Thus ...
![Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS | Journal of Chemical Information and Modeling Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS | Journal of Chemical Information and Modeling](https://pubs.acs.org/cms/10.1021/acs.jcim.6b00465/asset/images/large/ci-2016-004655_0010.jpeg)
Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS | Journal of Chemical Information and Modeling
![Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology](https://pubs.acs.org/cms/10.1021/acschembio.7b00903/asset/images/large/cb-2017-00903z_0007.jpeg)
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology
![New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/jm901137j/asset/images/large/jm-2009-01137j_0013.jpeg)
New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry
![New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/jm901137j/asset/images/large/jm-2009-01137j_0010.jpeg)
New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry
![New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/jm901137j/asset/images/medium/jm-2009-01137j_0009.gif)
New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry
![PDF] New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Semantic Scholar PDF] New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/dc74cc019e30ea0cba35ca71c2e5ca1bc731e89b/4-Figure1-1.png)
PDF] New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays. | Semantic Scholar
![New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/jm901137j/asset/images/large/jm-2009-01137j_0008.jpeg)
New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry
![Gains from no real PAINS: Where 'Fair Trial Strategy' stands in the development of multi-target ligands - ScienceDirect Gains from no real PAINS: Where 'Fair Trial Strategy' stands in the development of multi-target ligands - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S221138352100071X-gr5.jpg)
Gains from no real PAINS: Where 'Fair Trial Strategy' stands in the development of multi-target ligands - ScienceDirect
![New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/jm901137j/asset/images/large/jm-2009-01137j_0011.jpeg)
New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry
![Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology](https://pubs.acs.org/cms/10.1021/acschembio.7b00903/asset/images/large/cb-2017-00903z_0003.jpeg)
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology
![IJMS | Free Full-Text | Comparative Analyses of Medicinal Chemistry and Cheminformatics Filters with Accessible Implementation in Konstanz Information Miner (KNIME) IJMS | Free Full-Text | Comparative Analyses of Medicinal Chemistry and Cheminformatics Filters with Accessible Implementation in Konstanz Information Miner (KNIME)](https://www.mdpi.com/ijms/ijms-23-05727/article_deploy/html/images/ijms-23-05727-g008.png)
IJMS | Free Full-Text | Comparative Analyses of Medicinal Chemistry and Cheminformatics Filters with Accessible Implementation in Konstanz Information Miner (KNIME)
![Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology](https://pubs.acs.org/cms/10.1021/acschembio.7b00903/asset/images/medium/cb-2017-00903z_0006.gif)
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology
![KNIME Workflow to Assess PAINS Filters in SMARTS Format. Comparison of RDKit and Indigo Cheminformatics Libraries - Saubern - 2011 - Molecular Informatics - Wiley Online Library KNIME Workflow to Assess PAINS Filters in SMARTS Format. Comparison of RDKit and Indigo Cheminformatics Libraries - Saubern - 2011 - Molecular Informatics - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/da31eb67-cc0e-4424-8ce6-82c9c400c115/mcontent.gif)
KNIME Workflow to Assess PAINS Filters in SMARTS Format. Comparison of RDKit and Indigo Cheminformatics Libraries - Saubern - 2011 - Molecular Informatics - Wiley Online Library
![New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry](https://pubs.acs.org/cms/10.1021/jm901137j/asset/images/large/jm-2009-01137j_0012.jpeg)
New Substructure Filters for Removal of Pan Assay Interference Compounds ( PAINS) from Screening Libraries and for Their Exclusion in Bioassays | Journal of Medicinal Chemistry
![Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology](https://pubs.acs.org/cms/10.1021/acschembio.7b00903/asset/images/medium/cb-2017-00903z_0005.gif)
Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | ACS Chemical Biology
![Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | Semantic Scholar Seven Year Itch: Pan-Assay Interference Compounds (PAINS) in 2017—Utility and Limitations | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/982cdf91624b1cb66bfd25c22e2482094cbcbeb8/7-Figure4-1.png)